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General Hospital is the longest-running American television serial drama, airing on ABC since April 1, 1963. Created by Frank and Doris Hursley, it was originally set in a general hospital (hence the title) in an unnamed fictional city. In the 1970s, the city was named Port Charles, New York. This is a list of notable characters who significantly impacted storylines and began their run between 2010 and 2019.

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